Adults (18 years of age and over), including the elderly

A course of treatment consists of two separate non-identical 500 mL doses of PLENVU.

At least 500 mL of additional clear fluid, which may include water, clear soup, fruit juice

without pulp, soft drinks, tea and/or coffee without milk must be taken with each dose.

This course of treatment can be taken according to any of the three schedules specified

below:

• Two-day split dosing schedule with the first 500 mL dose of PLENVU (including

additional 500 mL of clear fluid) taken in the evening before the clinical procedure

(approximately 6 pm) and the second 500 mL dose (including additional 500 mL of

clear fluid) in the early morning of the day of the clinical procedure (approximately

6 am), or

• Morning only dosing schedule with both doses taken in the morning of the day of

the clinical procedure [the first 500 mL dose (including additional 500 mL of clear

fluid) taken at approximately 5 am]; the time between finishing the first dose

(including additional clear fluid) and starting the second 500 mL dose (including

additional 500 mL of clear fluid) should be separated by a minimum 1 hour

interval, or

• Day before dosing schedule with both doses taken in the evening before the

clinical procedure [the first 500 mL dose (including additional 500 mL of clear

fluid)] taken at approximately 6 pm]; the time between finishing the first dose

(including additional clear fluid) and starting the second 500 mL dose (including

additional 500 mL of clear fluid) should be separated by a minimum 1 hour

interval. A time interval of more than 12 hours between preparation administration

and colonoscopy may reduce the bowel cleansing efficacy.